BelloCell-500 bottle is a compact bioreactor and offers large surfaces for cell attachment to achieve high-density cell proliferation. During cell culture, the featured “Tide” movement of the Culture Medium, driven by BelloStage system, contributes to the unlimited oxygen supply and sufficient nutrient-waste transfer, and the porous carriers BioNOC II, where cells can attach, provide 15,600 cm² contact surface for cell growth.

One BelloCell-500 bottle is equivalent to dozens of roller bottles. It is applicable in seeding, binding assay/ human proteome/new drug discovery, virus production, recombinant protein production/ monoclonal antibody production, transient transfection, and tissue engineering.

 

 

 

The principle of BelloCell-500 is to immobilize cells onto the BioNOC II matrices packed in its upper chamber. By compressing and decompressing the bellow of BelloCelll-500 by BelloStage machine, the culture medium inside rises and descends, submerging and exposing matrices periodically. During aeration, cells attached to porous matrices are exposed to the air through a thin liquid film. In the submerging phase, cells are in direct contact with the fresh medium for up-taking nutrients while metabolic waste can be diffused as well as CO₂ can be exhausted efficiently. The concept of the design is to solve problems (shear stress, limited oxygen supply, and low cell density) frequently occurring on the commercial models, and to simplify the operation.

 

 

 

 

 

 

 

 

1.          Product Introduction

2.         Introduction of BelloCell and BelloStage

3.          All BelloCell Selection Guide

4.          Reference

5.       Q&A