TideCell Matrix Vessel
TideCell Matrix Vessel
Vessels are available with nominal working volumes of 2 L, 10 L, 20 L, and 100 L with various amount of BioNOCII matrices for either R&D or production purposes. Additionally, flexible pairing of the matrix vessel with mixing bag further reduces the system scale and facilitates the whole process.
Trade Description
Product Feature
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TideCell Matrix Vessel
Efficient, Versatile Matrix Vessel for High-density Cell Culture
l Similar principle to the roller bottle
l Scalable from 2 L, 10 L, 20 L to 100 L
l Both single-use and autoclavable options are available.
l Plug-and-play simple and fast turnaround
l Multiple ports to simplified applications such as cell inoculation, cell sampling, virus inoculation, components addition, or product harvest.
The TideCell Matrix Vessel is designed as a compact bioreactor to accommodate users from early process development through manufacturing in biopharmaceutical areas using mammalian cell cultures. It incorporates the “Tide” movement, in which the culture medium runs back-and-forth between the matrix vessel and mixing bag, driven by the applied air pressure. As a result, sufficient nutrient / oxygen supply improves the cell growth on / between the BioNOC II matrices in the vessel. This dynamic but gentle action promotes cell proliferation while preventing cell shearing.
Vessels are available with nominal working volumes of 2 L, 10 L, 20 L, and 100 L with various amount of BioNOCII matrices for either R&D or production purposes. Additionally, flexible pairing of the matrix vessel with mixing bag further reduces the system scale and facilitates the whole process.
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Single-Use Autoclavable
Specification:
Specification:
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2 L Matrix Vessel
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10 L Matrix Vessel
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20 L Matrix Vessel
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100 L Matrix Vessel
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Material
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Glass, PP
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Glass
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PP
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PP
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Product Contact Layer Material
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Borosilicate glass
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Borosilicate glass
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Polypropylene
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Polypropylene
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Color
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Clear, translucent
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clear
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Translucent
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Translucent
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Dimension (dia. × h)
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136 × 248 mm
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227 × 395 mm
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282 × 526 mm
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470 × 981 mm
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Min Fill Volume
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xx L
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xx L
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xx L
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xx L
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Max Fill Volume
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xx L
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xx L
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22.5 L
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xx L
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Packed with Matrix
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No
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with 55 g BioNOCII/ 110 g BioNOCII
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No
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with 275 g BioNOCII/ 550 g BioNOCII
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No
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No
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with 550 g BioNOCII/1100 g BioNOCII
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No
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No
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with 2,750 g BioNOCII/ 5,500 g BioNOCII
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Sterility
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Autoclavable (reusable)
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Gamma-irradiated (single-use)
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Autoclavable (reusable)
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Gamma-irradiated (single-use)
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Autoclavable (reusable)
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Gamma-irradiated (single-use)
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Gamma-irradiated (single-use)
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Autoclavable (reusable)
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Gamma-irradiated (single-use)
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Gamma-irradiated (single-use)
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Compliance
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DIN ISO 719
USP/EP
DIN 12 116
DIN ISO 695
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DIN ISO 719
USP/EP
DIN 12 116
DIN ISO 695
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Cytotoxicity
USP Class VI
FDA 21 CFR 177. 178, 181
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Cytotoxicity
USP Class VI
FDA 21 CFR 177. 178, 181
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Shelf Life
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Unlimited
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2 years
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Unlimited
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2 years
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Unlimited
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2 years
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2 years
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Unlimited
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2 years
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2 years
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Packaging
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Individual bag, labels with product number, description, and expiration date
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clean double-bagged, labels with gamma indicator, product number, description, and expiration date
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Individual bag, labels with product number, description, and expiration date
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clean double-bagged, labels with gamma indicator, product number, description, and expiration date
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Individual bag, labels with product number, description, and expiration date
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clean double-bagged, labels with gamma indicator, product number, description, and expiration date
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Individual bag, labels with product number, description, and expiration date
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clean double-bagged, labels with gamma indicator, product number, description, and expiration date
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Compatibility
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TideCell-002 High-density Cell Culture System
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TideCell-010 High-density Cell Culture System
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TideCell-020 High-density Cell Culture System
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TideCell-100 High-density Cell Culture System
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Principle:
TideCellMatrix Vessel inherits the same patented principle of BelloCell bottles. Packed with porous BioNOC II matrices, the matrix vessel functions as an artificial lung with a huge contact surface for nutrition and aeration for cell culture. The culture medium is periodically drawn from the external medium bag (Mixing Bag) into the matrix vessel to submerge the matrices and withdrawn from the vessel to expose the matrices, driven by the applied air pressure. Thus, cells entrapped inside the matrices are able to receive sufficient nutrients and oxygen, while metabolic wastes such as lactate and carbon dioxide can be efficiently carried away in a gentle manner. The concept of the design is to solve problems (shear stress, limited oxygen supply, and low cell density) frequently occurring on the commercial models, and to simplify the operation.
Performance:
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TideCell Matrix Vessel
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Output
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Up to 5 × 109 cells for 2 L matrix vessel; Up to 2.5 × 1010 cells for 10 L matrix vessel; Up to 5 × 1010 cells for 20 L matrix vessel; Up to 2.5 × 1011 cells for 100 L matrix vessel
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Matrix Vessel/Medium Ratio (v/v)
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Adjustable from 1:2, 1:5, 1:10 to 1:20
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Scalability
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Up to 100 L packed bed
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Homogeneity of Nutrient/ O2
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High in both a horizontal and vertical direction
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Shear Stress
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Low
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Foaming
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No
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Cell Doubling Time
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Shorter
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Direct Cell Count
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Yes
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CPE Observation
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Yes
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Resource:
1. Product Introduction
2. TideCell Brochure
3. Reference
Order Information:
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Product
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Cat. No.
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Availability
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TideCell Matrix Vessel 2 L, 1pc/pk (Empty)
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TCV10020
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Contact CESCO Bioengineering
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TideCell Matrix Vessel 2 L (55 g BioNOCII), 1pc/pk
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TCV20055
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Contact CESCO Bioengineering
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TideCell Matrix Vessel 2 L (110 g BioNOCII), 1pc/pk
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TCV20110
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Contact CESCO Bioengineering
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TideCell Matrix Vessel 10 L, 1pc/pk (Empty)
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TCV10100
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Contact CESCO Bioengineering
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TideCell Matrix Vessel 10 L (275 g BioNOCII), 1pc/pk
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TCV20275
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Contact CESCO Bioengineering
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TideCell Matrix Vessel 10 L (550 g BioNOCII), 1pc/pk
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TCV20550
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Contact CESCO Bioengineering
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TideCell Matrix Vessel 20 L, 1pc/pk (Empty)
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TCV10200
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Contact CESCO Bioengineering
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TideCell Matrix Vessel 20 L, (550 g BioNOCII ), 1pc/pk
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TCV2055A
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Contact CESCO Bioengineering
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TideCell Matrix Vessel 20 L, (1,100 g BioNOCII ), 1pc/pk
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TCV21100
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Contact CESCO Bioengineering
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TideCell Matrix Vessel 100 L, 1pc/pk (Empty)
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TCV11000
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Contact CESCO Bioengineering
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TideCell Matrix Vessel 100 L, (2,750 g BioNOCII ),1pc/pk
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TCV22750
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Contact CESCO Bioengineering
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TideCell Matrix Vessel 100 L, (5,550 g BioNOCII ),1pc/pk
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TCV25500
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Contact CESCO Bioengineering
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